Physical Stability of therapeutic proteins in solution

About The Event

Therapeutic proteins have revolutionised the treatment of diseases by enabling the functional replacement of faulty proteins and the precise targeting of pathogenic pathways. However, maintaining the native structure of these proteins is crucial to their function, and they are often sensitive to stress factors such as temperature fluctuations, mechanical agitation, and interactions with various surfaces. These stressors can arise during production, transport, storage, or administration, leading to protein aggregation.  Aggregation may reduce therapeutic efficacy and increase the risk of immunogenic responses. Because aggregation is system-dependent and affected by protein type, solution conditions (pH, excipients, concentration), and specific stressors, it remains a challenging yet fundamental phenomenon to study and mitigate. Addressing this challenge requires the use of multiple biophysical technologies.  In this seminar, you’ll learn about the findings from a recent study on the stability and aggregation behaviours of therapeutic proteins in solution. You’ll learn how physical stability and aggregation were examined using an array of biophysical technologies and how stresses such as heat and pumping interplay with the intrinsic properties of the proteins to induce aggregation.