Challenges in measurement and modelling of complex crystallising systems

About The Event

Biologically active molecules commonly contain one or more chiral centres. The chemical synthesis of these molecules usually produces a mixture of the enantiomers, rather than a pure single enantiomer. The enantiomers formed may also express different biological outcomes, hence there is a need to separate and purify the desired form. Often, the most efficient way of doing this, is in the crystallisation stage, such that the preferred form is isolated without downstream processing. To optimise the crystallisation process, we are developing a population balance model for the system using particle size and shape data as inputs. In this example, we present data from a very complex system involving not only enantiomers but also co-crystal forms too. Attendees will learn about how we collected data using the Mastersizer 3000 and Hydro Insight accessory and used the Siemens gPROMS platform to develop a model of the system.