Biodegradable Microneedle Arrays for Blood Pressure Control - Ask an Expert

About The Event

The aim of this work was to develop and characterize biodegradable polymeric microneedle arrays loaded with (i) losartan potassium powder and (ii) nanoparticles loaded with losartan potassium dispersed in a polymeric matrix (starch/gelatin), as innovative pharmaceutical forms intended to be used for blood pressure control. The lecithin/gelatin nanoparticles were prepared by the desolvation method. The independent variables were the lecithin/gelatin amount and the stirring speed, while particle size, PDI (polydispersity index), and entrapment efficiency were the dependent variables studied. The optimized nanoparticle formulation was also characterized in terms of ζ potential and morphology. The mold of the microneedle manufacture was created using a 3D printer by molding, and the microneedle arrays were prepared using the micromolding method. The independent variables were the starch/gelatin amount and drug form, while the fracture force, bioadhesion, and post-wetting bioadhesion were the dependent variables evaluated. The optimized microneedle array formulations were also characterized and evaluated in terms of morphology, release profiles, and in-vitro losartan skin permeation studies. The optimized nanoparticle formulation was of 170.3 ± 3.1 nm in size, with 0.201 ± 0.013 of PDI, 40.45 ± 2.27% of entrapment efficiency, and − 32.9 ± 0.8 mV of ζ potential. The mold had an array of 25 microneedles with a height of 1.5 mm each. The optimized microneedle arrays were successful in terms of fracture force, with a value of 408.3 ± 6.1 gf for MP and 320.2 ± 17.4 gf for MN. The results of in-vitro skin permeation studies indicated that therapeutic losartan concentrations can be reached by using a microneedle array of 49 cm2 for MP and 13 cm2 for MN. The optimal formulation of the microneedle array with nanoparticles constitutes the most suitable option for skin losartan delivery. For inclusion in the webinar presentation, questions and data can be submitted up to 10 days in advance by emailing askanexpert@malvernpanalytical.com. There is also the opportunity to ask questions on the day.