- 10am: Pushing the Boundaries in Biomolecular Interaction Analysis
- From Biologics to Fragment-Based Drug Discovery with label free analysis using Grating-Couple Interferometry
- How GCI compares to other methods like SPR
- 10.45am: Break
- 11am: Applying the use of GCI
- 11.30am: Complementary techniques using ITC: The "Gold Standard" for measuring binding affinity and stoichiometry
- 12pm: End
- Drug discovery scientists
- Anyone who is using high-throughput analytical techniques like Surface Plasmon Resonance (SPR) and Enzyme-Linked Immunosorbent Assays (ELISAs) and would like to learn about new cutting edge methods for determining the binding affinity of drug candidates to drug targets.
- How to accelerate your discovery research from small molecules to biologics
- From Grating-Couple Interferometry (GCI) technology’s RAPID analysis for determining the binding kinetics of drug candidates to drug targets
- To orthogonal validation and in-depth biophysical characterization
- Learn through case studies and hands-on time with the GCI and ITC techniques
- Book 1-on-1 time over here
- To discuss your challenges or book a demo to test the quality of our instruments; namely:
- label-free quantification analysis using real-time binding affinity and kinetics using the Creoptix® WAVEsystem GCI
- isothermal titration calorimetry (ITC analysis), the gold standard for measuring binding affinity and stoichiometry
Singapore Workshop: Delivering a breakthrough level of interaction analysis to facilitate drug discovery
Introducing the patented GCI technique for label-free analysis
7 April, 10am - 12pm, Singapore
About The Event
The accurate and efficient measurement of intermolecular interactions and binding events is a critical element for all manner of basic research and an indispensable component of drug discovery programs. Ligand binding assays can be performed using labeled molecules (radiolabels, fluorescent labels, etc.), but appropriate, non-disruptive labeling and often elaborate washing and purification steps are required. Additionally, the kinetics of interactions are not easily acquired or understood using these methods. Surface plasmon resonance (SPR) changed the game with its ability to monitor and measure interactions in real time using unlabeled species, but challenges remain. Measurements usually require significant time investment because they involve repeated introductions of increasing concentrations of analyte, and they are sensitive to bulk refractive index changes in buffers; these issues limit the utility of SPR in screening programs. Join us for a free workshop on high throughput analysis for binding affinity and kinetics. During the workshop, learn how to accelerate your discovery research from small molecules to biologics, from GCI’s RAPID analysis for determining the binding kinetics of drug candidates to drug targets to orthogonal validation and in-depth biophysical characterization. Gain greater insights through case studies and hands-on time with the GCI and ITC techniques. We are proud to have on display the waveRAPID®, which is the most sensitive optical sensing-based label-free analysis standard.
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