Rapid Screening for Binding Kinetics and Orthogonal Validation Using GCI and ITC 

About The Event

Join us for a free seminar that will ignite your curiosity and expand your horizons! We are thrilled to present "Rapid Screening for Binding Kinetics and Orthogonal Validation Using GCI and ITC," delivered by the brilliant Stoyan Milev, Sr. Field Application Scientist. This seminar will take place on Sunday, February 16, from 11:30 AM to 1:00 PM in Room 404B. In this talk, you will learn about the fundamental importance of understanding molecular interactions in drug discovery and biomolecular research. We will delve into key parameters such as affinity, kinetic rates, and thermodynamic profiles that provide essential insights into binding mechanisms. Stoyan will present an innovative approach utilizing Grating-Coupled Interferometry (GCI) for rapid kinetic screening and Isothermal Titration Calorimetry (ITC) for orthogonal validation of selected hits. Highlights of the Seminar: GCI: A high-throughput, label-free solution for real-time kinetic analysis, enabling rapid screening of binding events with minimal sample consumption. GCI provides binding rate constants and affinity data with high sensitivity and delivers both association and dissociation rate constants at the initial screening stage using only one concentration. ITC: A solution-based, label-free method for validating hits, adding a comprehensive thermodynamic perspective. ITC measures binding affinity (Kd), enthalpy (ΔH), entropy (ΔS), stoichiometry, and the activity of binding components, offering a robust orthogonal validation of the kinetic data. Combined Approach: Enhancing the confidence and reliability of binding characterizations, supporting more informed decision-making in drug development pipelines. Additionally, Malvern Panalytical will be exhibiting at Booth #412, showcasing our cutting-edge technology, including the Zetasizer range, the NanoSight Pro, and the WAVEsystem. Whether you're in industry or academia, these innovations are set to revolutionize your research and development. Special Bonus: The first 25 attendees to sign up will receive a complimentary gift upon arrival. Do not miss out on this unique opportunity to be at the forefront of scientific innovation. Same-day registrations are always welcome. We look forward to seeing you there!